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Cardiovascular Disease Risk Reduction Advances in Dyslipidemia

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Presentation on theme: "Cardiovascular Disease Risk Reduction Advances in Dyslipidemia"— Presentation transcript:

1 Cardiovascular Disease Risk Reduction Advances in Dyslipidemia

2 Guideline Recommendations

3 Approximate Dose Equivalency of Statin LDL-C Efficacy

4 NEPTUNE II Trial

5 Residual CV Risk

6 Intensive Statin Therapy: Residual CV Risk

7 Combination Therapy

8 Statin + Fibrates

9

10 VA-HIT: Gemfibrozil Prevents Secondary CVD Events

11

12 ACCORD Lipid: Hazard Ratios for the Primary Outcome

13 Comparison of ACCORD Subgroup Results With Those From Prior Fibrate Studies

14 Statin + Niacin

15

16 AIM-HIGH: End Point at 36-month Follow-Up

17 HPS2-THRIVE: Effects of Niacin/Laropiprant on Lipids

18 HPS2-THRIVE: Major Vascular Events

19 Statin + Ezetimibe

20 Statin and Ezetimibe Trials

21 Statin and Ezetimibe

22 ENHANCE Simvastatin/Ezetimibe in Familial Hypercholesterolemia

23 ENHANCE Simvastatin/Ezetimibe in High Cholesterol Absorbers and Synthesizers

24 ENHANCE Change in Intima Media Thickness of Carotid Artery

25 EZ-Switch Study: Ezetimibe Added to Atorvastatin vs Atorvastatin Up-Titration or Switching to Rosuvastatin

26 LDL-C: Percentage Change From Baseline at End of Phase 1/2

27 ARBITER 6-HALTS Trial

28

29 Statin + Bile Acid Sequestrants

30

31 Comparison of CETP Inhibitors

32 DAL-OUTCOMES: 3 Years

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37 Abbreviations

38 Abbreviations (cont)

39 Abbreviations (cont)


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