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The Aging Liver in the Aging HIV and HCV Patients

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Presentation on theme: "The Aging Liver in the Aging HIV and HCV Patients"— Presentation transcript:

1 The Aging Liver in the Aging HIV and HCV Patients

2 The HIV-Infected Population is Aging

3 Persons Living with HIV/AIDS in USA CDC Surveillance Program

4 HIV Results in Accelerated Age-related Conditions

5 Change in Causes of Death in Persons with HIV Reflects Aging

6 Change in Causes of Death in Patients with HIV Reflects Aging

7 HCV Status Strongly Influences Causes of Death in HIV-Infected Patients

8

9 Aging, HIV and the Immune System: Interactions

10 HIV and Microbial Translocation

11 Microbial Translocation in HIV

12 Early Immune Senescence in HIV Disease

13 Aging, HIV and the liver: Interactions

14 Aging, HIV and the liver: Interactions

15

16 Chronic Elevation of Liver Enzymes in HIV

17 Chronic Elevation of Liver Enzymes in HIV

18 The HIV Aging Liver and Steatosis

19 Drug-Induced Liver Injury

20 HCC in HIV-Infected Patients

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22 Age and HCC in HIV-Infected Patients

23 HCC in HIV-Infected Patients

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25 Age and HCC in HIV-Infected Patients

26 Non Cirrhotic Portal Hypertension: Long-Term Liver Complication of ART

27 Aging and HIV also Impact HCV

28 Early Immunosenescence with HCV?

29 HCV-Infected Persons Are Aging

30 HCV-Related Cirrhosis prevalence Is Projected to Peak Over the Next 10 Years

31 Liver fibrosis is Accelerated in HIV/HCV Co-Infected Patients

32 Baseline Fibrosis Stage According to Age in HIV/HCV Co-Infection

33 HIV-related Microbial Translocation and Progression of Hepatitis C

34 Role of Microbial translocation in liver fibrosis?

35

36 HIV-related Gut CD4+ T cell Depletion and Microbial Translocation Contributes to HCV Progression

37 sCD14 on first 33 patients

38 Baseline Fibroscan Scores in HCV Mono-infected Patients

39 Baseline Fibroscan Scores in HIV/HCV Co-infected Patients

40 sCD14 Values of 7 Patients with Increasing FibroScan Scores Over 12 Months

41 HIV-related Microbial Translocation and Progression of Hepatitis C

42 Conclusions

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44 Change in Causes of Death in Persons with HIV Reflects Aging

45 HCV Status Strongly Influences Causes of Death in HIV-Infected Patients

46 Early Immune Senescence in HIV Disease

47 Steatosis/Steatohepatitis Is an Emerging Cause of Liver Disease in HIV

48 Steatosis/Steatohepatitis Is an Emerging Cause of Liver Disease in HIV


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