1. UNDERSTANDING RISK STRATIFICATION IN PAH:

3. PAH Burden of Disease

4. The Rationale for Evaluation of PAH Severity

5. ESC/ERS Pulmonary Hypertension Guidelines: Parameters of a Comprehensive Risk Assessment

6. Comprehensive Prognostic Evaluation and Risk Assessment

7. PAH Expert Referral Centers

8. Definition of Patient Status

9. Classification of WHO Group 1 (PAH)

10. Components of a Comprehensive Risk Assessment

11. Suggested Assessment and Timing for Follow-Up of Patients with PAH

12. Case 1: 45-Year-Old Woman With Idiopathic PAH Before Starting Treatment

13. Case 1: 45-Year-Old Woman With Idiopathic PAH Before Starting Treatment (cont)

14. Evidence-Based Treatment Algorithm for Patients With PAH

15. Case 1: 45-Year-Old Woman With Idiopathic PAH After 4 Months of Treatment With Initial Oral Combination Therapy (PDE5 Inhibitor + ERA)

16. Case 1: 45-Year-Old Woman With Idiopathic PAH After 4 Months of Treatment With Initial Oral Combination Therapy (PDE5 Inhibitor + ERA) (cont)

17. Case 1: 45-Year-Old Woman With Idiopathic PAH After 4 Months of Treatment With Initial Oral Combination Therapy (PDE5 Inhibitor + ERA) (cont)

18. Evidence-Based Treatment Algorithm for Patients With PAH

19. ESC/ERS Recommendations for Sequential Drug Combination Therapy for PAH

20. Case 2: 34-Year-Old Man With Idiopathic PAH: Syncope and Breathlessness for 2 Years at Baseline

21. Case 2: 34-Year-Old Man With Idiopathic PAH: Syncope and Breathlessness for 2 Years at Baseline (cont)

22. Case 2: 34-Year-Old Man With Idiopathic PAH After 4 Months of Combination Therapy With Intravenous Epoprostenol

23. Case 2: 34-Year-Old Man With Idiopathic PAH After 4 Months of Combination Therapy With Intravenous Epoprostenol (cont)

24. Case 3: 64-Year-Old Woman With Scleroderma-Associated PAH at Baseline

25. Case 3: 64-Year-Old Woman With Scleroderma-Associated PAH at Baseline (cont)

26. AMBITION: Initial Combination Therapy Improves Patient Outcomes vs Monotherapy in FC II Patients With PAH

27. Conclusions

28. Abbreviations

29. Abbreviations (cont)