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Turning Up the Heat on Membrane Fluidity

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Presentation on theme: "Turning Up the Heat on Membrane Fluidity"— Presentation transcript:

1 Turning Up the Heat on Membrane Fluidity
Weiwei Fan, Ronald M. Evans  Cell  Volume 161, Issue 5, Pages (May 2015) DOI: /j.cell Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 Cold- and Heat-Induced Homeoviscous Adaptation in C. elegans
In low temperature, PAQR-2 mediates cold-induced signaling through NHR-49 to induce the expression of FAT-7, which increases unsaturated lipid contents in cellular membrane and offsets the cold-induced reduction in membrane fluidity. Heat induces the expression of ACDH-11, which sequesters intracellular C11/12 fatty acids and reduces NHR-49-regulated FAT-7 expression. This leads to reduced unsaturated lipid contents and offsets the heat-induced increase in membrane fluidity. Cell  , DOI: ( /j.cell ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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