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Quantitative trait locus on chromosome 8q influences the switch from fetal to adult hemoglobin by Chad Garner, Nicholas Silver, Steve Best, Stephan Menzel,

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Presentation on theme: "Quantitative trait locus on chromosome 8q influences the switch from fetal to adult hemoglobin by Chad Garner, Nicholas Silver, Steve Best, Stephan Menzel,"— Presentation transcript:

1 Quantitative trait locus on chromosome 8q influences the switch from fetal to adult hemoglobin
by Chad Garner, Nicholas Silver, Steve Best, Stephan Menzel, Charlotte Martin, Tim D. Spector, and Swee Lay Thein Blood Volume 104(7): October 1, 2004 ©2004 by American Society of Hematology

2 Multipoint linkage analysis of XmnI-Gγ adjusted and unadjusted FC traits across 56 cM of chromosome 8q. Multipoint linkage analysis of XmnI-Gγ adjusted and unadjusted FC traits across 56 cM of chromosome 8q. Single-point lod scores from the original study are shown with bars above the markers tested. Because of missing genotype data, 315 of the 319 total twin pairs were used in the multipoint analysis. *Markers were used in the original linkage study in the Asian Indian kindred but not in the multipoint analysis. Chad Garner et al. Blood 2004;104: ©2004 by American Society of Hematology


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