1. Oral Anticoagulant Therapy
Walter Ageno, MD, Alexander S. Gallus, MBBS, Ann Wittkowsky, PharmD, FCCP, Mark Crowther, MD, Elaine M. Hylek, MD, MPH, Gualtiero Palareti, MD 
CHEST 
Volume 141, Issue 2, Pages e44S-e88S (February 2012)
DOI: /chest
Copyright © 2012 The American College of Chest Physicians Terms and Conditions

2. Figure 1
[Section 1.1] Vitamin K1 is reduced to vitamin KH2. The major warfarin-sensitive enzyme in this reaction is the vitamin K oxide reductase mainly inhibited by the S-enantiomer of warfarin. S-warfarin is metabolized by the p450 cytochrome enzyme, CYP2C9. Reprinted with permission from Ansell et al.8
CHEST  , e44S-e88SDOI: ( /chest )
Copyright © 2012 The American College of Chest Physicians Terms and Conditions