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Clinical characteristics of patients with low functional IL-6 production upon TLR/IL-1R stimulation  Glynis Frans, MPharm, PhD, Jutte Van der Werff Ten.

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Presentation on theme: "Clinical characteristics of patients with low functional IL-6 production upon TLR/IL-1R stimulation  Glynis Frans, MPharm, PhD, Jutte Van der Werff Ten."— Presentation transcript:

1 Clinical characteristics of patients with low functional IL-6 production upon TLR/IL-1R stimulation 
Glynis Frans, MPharm, PhD, Jutte Van der Werff Ten Bosch, MD, PhD, Leen Moens, PhD, Greet Wuyts, BSc, Heidi Schaballie, MD, David Tuerlinckx, MD, Mia De Bie, MD, Francois Vermeulen, MD, Rik Schrijvers, MD, PhD, Wim Meert, MSc, Matthew S. Hestand, PhD, Joris Delanghe, MD, PhD, Joris R. Vermeesch, PhD, Isabelle Meyts, MD, PhD, Xavier Bossuyt, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 141, Issue 2, Pages (February 2018) DOI: /j.jaci Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 IL-6 production by PBMCs from 770 patients. Dots represent individual IL-6 measurements from 22 patients with a confirmed abnormal response to TIR ligands. For each ligand, only those results that fell below the cutoff value are displayed. Green dots indicate results from patient 21 with NEMO-ID (rs ). Red dots indicate results from patient 8 with IRAK-4 deficiency (rs ). Boxplots (median ± IQR) represent patients with normal IL-6 responses after TIR stimulation. Black lines below the boxes indicate the established cutoff values for each TIR ligand. IQR, Interquartile range. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Infectious and microbiological histories. Data on the type of infections and their microbiological cause (divided into invasive and noninvasive infections) for patients tested for IL-1R and TLR function from whom medical health records were available. Patients with a normal IL-6 response (n = 368) were compared with patients with a low IL-6 response (n = 22) to TIR ligands. Relevant P values are displayed. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig E1 Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig E2 Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig E3 Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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