1. SGLT2 Inhibitors and Their Clinical Impact:

2. Ominous Octet

4. Renal Handling of Glucose

6. Active (SGLT2) and Passive (GLUT2) Glucose Transport in a Renal Proximal Tubule Cell

7. Renal Glucose Transport GLUTs

8. Altered Renal Glucose Control in T2D

9. Renal Threshold for Glucose Excretion

10. Inhibiting SGLT2 Promotes Urinary Glucose Excretion

11. Rationale for Inhibiting SGLT2 to Manage Hyperglycemia in T2D

12. Naturally Occurring Reduction in SGLT2 Function

13. Historical Selective Targeting (Phlorizin)

18. Fixed-Dose Combination Therapy SGLT2 Inhibitor and DPP-4 Inhibitor

19. Efficacy of Empagliflozin/Linagliptin Added to Metformin

20. Efficacy of Dapagliflozin/Saxagliptin Added to Metformin

22. The Future for SGLT Inhibitors

23. Summary Take-Home Points

24. Summary Take-Home Points (cont)

25. Abbreviations

26. References

27. References (cont)

28. References (cont)

29. References (cont)