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Plasma concentrations and sedation scores after nebulized and intranasal midazolam in healthy volunteers A.S.M. McCormick, V.L. Thomas, D. Berry, P.W. Thomas British Journal of Anaesthesia Volume 100, Issue 5, Pages (May 2008) DOI: /bja/aen072 Copyright © 2008 British Journal of Anaesthesia Terms and Conditions
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Fig 1 Ramsay sedation scores in the nebulized and nasal groups [mean (2sem)]. Mean (sd) AUC: nebulized=163 (56.7), nasal=206 (60.1); P=0.005. British Journal of Anaesthesia , DOI: ( /bja/aen072) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions
![Fig 1 Ramsay sedation scores in the nebulized and nasal groups [mean (2sem)]. Mean (sd) AUC: nebulized=163 (56.7), nasal=206 (60.1); P=](http://slideplayer.com./slide/14590984/90/images/2/Fig+1+Ramsay+sedation+scores+in+the+nebulized+and+nasal+groups+%5Bmean+%282sem%29%5D.+Mean+%28sd%29+AUC%3A+nebulized%3D163+%2856.7%29%2C+nasal%3D206+%2860.1%29%3B+P%3D.jpg "British Journal of Anaesthesia , DOI: ( /bja/aen072) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions.")
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Fig 2 Visual analogue scores in the nebulized and nasal groups [mean (2sem)]. Mean (sd) AUC: nebulized=3924 (932.1), nasal=2763 (663.9); P<0.001. British Journal of Anaesthesia , DOI: ( /bja/aen072) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions
![Fig 2 Visual analogue scores in the nebulized and nasal groups [mean (2sem)]. Mean (sd) AUC: nebulized=3924 (932.1), nasal=2763 (663.9); P<](http://slideplayer.com./slide/14590984/90/images/3/Fig+2+Visual+analogue+scores+in+the+nebulized+and+nasal+groups+%5Bmean+%282sem%29%5D.+Mean+%28sd%29+AUC%3A+nebulized%3D3924+%28932.1%29%2C+nasal%3D2763+%28663.9%29%3B+P%3C.jpg "British Journal of Anaesthesia , DOI: ( /bja/aen072) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions.")
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Fig 3 Critical flicker fusion frequency (Hz) [mean (2sem)]. Mean (sd) AUC: nebulized=1439 (430), nasal 966 (481); P=0.02. British Journal of Anaesthesia , DOI: ( /bja/aen072) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions
![Fig 3 Critical flicker fusion frequency (Hz) [mean (2sem)]. Mean (sd) AUC: nebulized=1439 (430), nasal 966 (481); P=0.02.](http://slideplayer.com./slide/14590984/90/images/4/Fig+3+Critical+flicker+fusion+frequency+%28Hz%29+%5Bmean+%282sem%29%5D.+Mean+%28sd%29+AUC%3A+nebulized%3D1439+%28430%29%2C+nasal+966+%28481%29%3B+P%3D0.02..jpg "British Journal of Anaesthesia , DOI: ( /bja/aen072) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions.")
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Fig 4 Oxygen saturations (%) [mean (2sem)]. Mean (sd) AUC: nebulized=5783 (46.5), nasal 5805 (53.9); P=0.32. British Journal of Anaesthesia , DOI: ( /bja/aen072) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions
![Fig 4 Oxygen saturations (%) [mean (2sem)]. Mean (sd) AUC: nebulized=5783 (46.5), nasal 5805 (53.9); P=0.32.](http://slideplayer.com./slide/14590984/90/images/5/Fig+4+Oxygen+saturations+%28%25%29+%5Bmean+%282sem%29%5D.+Mean+%28sd%29+AUC%3A+nebulized%3D5783+%2846.5%29%2C+nasal+5805+%2853.9%29%3B+P%3D0.32..jpg "British Journal of Anaesthesia , DOI: ( /bja/aen072) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions.")
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Fig 5 Systolic arterial pressure (mm Hg) [mean (2sem)]. Mean (sd) AUC: nebulized=6652 (1065.2), nasal=7089 (1022); P=0.07. British Journal of Anaesthesia , DOI: ( /bja/aen072) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions
![Fig 5 Systolic arterial pressure (mm Hg) [mean (2sem)]. Mean (sd) AUC: nebulized=6652 (1065.2), nasal=7089 (1022); P=0.07.](http://slideplayer.com./slide/14590984/90/images/6/Fig+5+Systolic+arterial+pressure+%28mm+Hg%29+%5Bmean+%282sem%29%5D.+Mean+%28sd%29+AUC%3A+nebulized%3D6652+%281065.2%29%2C+nasal%3D7089+%281022%29%3B+P%3D0.07..jpg "British Journal of Anaesthesia , DOI: ( /bja/aen072) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions.")
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Fig 6 Diastolic arterial pressure (mm Hg) [mean (2sem)]. Mean (sd) AUC: nebulized=4031 (638.5), nasal=4494 (498.1); P=0.001. British Journal of Anaesthesia , DOI: ( /bja/aen072) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions
![Fig 6 Diastolic arterial pressure (mm Hg) [mean (2sem)]. Mean (sd) AUC: nebulized=4031 (638.5), nasal=4494 (498.1); P=](http://slideplayer.com./slide/14590984/90/images/7/Fig+6+Diastolic+arterial+pressure+%28mm+Hg%29+%5Bmean+%282sem%29%5D.+Mean+%28sd%29+AUC%3A+nebulized%3D4031+%28638.5%29%2C+nasal%3D4494+%28498.1%29%3B+P%3D.jpg "British Journal of Anaesthesia , DOI: ( /bja/aen072) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions.")
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Fig 7 Heart rate [mean (2sem)]. Mean (sd) AUC: nebulized=4235 (272.9), nasal=4526 (401.4); P=0.03. British Journal of Anaesthesia , DOI: ( /bja/aen072) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions
![Fig 7 Heart rate [mean (2sem)]. Mean (sd) AUC: nebulized=4235 (272.9), nasal=4526 (401.4); P=0.03.](http://slideplayer.com./slide/14590984/90/images/8/Fig+7+Heart+rate+%5Bmean+%282sem%29%5D.+Mean+%28sd%29+AUC%3A+nebulized%3D4235+%28272.9%29%2C+nasal%3D4526+%28401.4%29%3B+P%3D0.03..jpg "British Journal of Anaesthesia , DOI: ( /bja/aen072) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions.")
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Fig 8 Plasma midazolam concentrations (μg litre−1) [mean (2sem)]. Mean (sd) AUC: nebulized=1670 (778.0), nasal=4785 (1329.6); P<0.001. British Journal of Anaesthesia , DOI: ( /bja/aen072) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions
![Fig 8 Plasma midazolam concentrations (μg litre−1) [mean (2sem)]. Mean (sd) AUC: nebulized=1670 (778.0), nasal=4785 (1329.6); P<](http://slideplayer.com./slide/14590984/90/images/9/Fig+8+Plasma+midazolam+concentrations+%28%CE%BCg+litre%E2%88%921%29+%5Bmean+%282sem%29%5D.+Mean+%28sd%29+AUC%3A+nebulized%3D1670+%28778.0%29%2C+nasal%3D4785+%281329.6%29%3B+P%3C.jpg "British Journal of Anaesthesia , DOI: ( /bja/aen072) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions.")
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