1. Figure 2 Multiscale modelling in oncology
Figure 2 | Multiscale modelling in oncology. Multiscale modelling can be used to simulate physical or physiological processes related to cancer development. Simulations can be performed at the level of molecules and their interactions, at the cellular level, the tissue level, the organ level, and/or the ultimately at the whole-body level, over different time frames. Then, the effects of several inputs, such as molecular or genetic profiling, or grading and staging of the tumours, can be modelled. Characteristics of the anticancer agents alone or combination can also be computed via a PK/PD model. The model can eventually predict different kinds of outcome at each level (survival, clinical and biological toxicities, decreases in tumour volume, target inhibition, and molecular pathway inhibition) and at different time points.
Barbolosi, D. et al. (2015) Computational oncology — mathematical modelling of drug regimens for precision medicine
Nat. Rev. Clin. Oncol. doi: /nrclinonc