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The Tailless Root of Glioma: Cancer Stem Cells

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1 The Tailless Root of Glioma: Cancer Stem Cells
Qi Xie, William A. Flavahan, Shideng Bao, Jeremy Rich  Cell Stem Cell  Volume 15, Issue 2, Pages (August 2014) DOI: /j.stem Copyright © 2014 Elsevier Inc. Terms and Conditions

2 Figure 1 The Role of the Nuclear Orphan Receptor TLX in Glioblastoma
TLX-positive glioma cells are quiescent and display the capacity for self-renewal and tumor growth. TLX marks a subpopulation of tumor cells distinct from other putative cancer stem cell (CSC) markers—SOX2 and OLIG2—suggesting the potential for different pools of CSCs or further stages in a cellular hierarchy with SOX2 potentially indicating a transient amplifying progenitor population. Cell Stem Cell  , DOI: ( /j.stem ) Copyright © 2014 Elsevier Inc. Terms and Conditions


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