1. To Titrate or Not: Optimizing Treatment With Antiepileptic Drugs

3. Program Goals

4. Epilepsy Prevalence in the United States

5. Epilepsy Burden

6. Epilepsy Treatment

7. Major Depression is Associated With Uncontrolled Seizures

8. Adverse Events are Common in Epilepsy Patients Retrospective Observational Study

9. Seizure Frequency Significant Inverse Predictor of HRQoL Across All Domains

10. AED Titration

11. Case #1 23-Year-Old Woman With 3rd Episode of Focal Seizures

13. After Failing Initial First-Line Therapy

14. Case #2 25-Year-Old Male Veteran with History of Post-Traumatic Epilepsy

15. Interactions Between AEDs

16. AEDs and Psychiatric Adverse Effects

17. Strategies for Treating Drug-Resistant Epilepsy Partial Onset Seizures

18. Rapid vs Slow Titration

19. Eslicarbazepine Titration and Adverse Effects

20. Strategies for Treating Drug-Resistant Epilepsy: Partial Onset Seizures (cont)

21. Case #3 70-Year-Old Man With Focal Seizures Secondary to Stroke (1½ Years Ago)

22. Managing AED Therapy in the Elderly

23. Pharmacogenomic Considerations in AED Metabolism

24. Epilepsy in the Elderly

25. VA Study: Discontinuation Due to AEs At 12 months

26. Newer AEDs Oxcarbazepine & Eslicarbazepine vs Carbamazepine

27. Principles in Avoiding Adverse Effects With AED Therapy

28. Abbreviations

29. References

30. References (cont)

31. References (cont)

32. References (cont)

33. References (cont)