1. The Role of MRD in Hematologic Malignancies

2. Educational Objectives

3. Minimal Residual Disease

4. Minimal Residual Disease (cont)

5. Flow Cytometry

6. MRD Sensitivity Using Flow Cytometry By Disease State

7. Genetic Methods for MRD Quantification

8. Genetic Methods for MRD Quantification (cont)

9. Genetic Methods for MRD Quantification (cont)

10. Allele-Specific Oligonucleotide (ASO)-PCR

11. MRD Methods – Next Generation Sequencing

13. MRD Methods -- Next Generation Sequencing (cont)

14. MRD Methods -- Next Generation Sequencing (cont)

15. MRD Methods -- Next Generation Sequencing (cont)

16. ASO-PCR vs NGS

18. Comparison of MRD Assessment Approaches

19. Current Role of MRD Assessment in Clinical Care

20. MRD in Acute Lymphoblastic Leukemia Children's Oncology Group AALL0232

21. COG AALL0232: Outcomes

24. ALL: Outcomes by Quantitative MRD Ranges

25. MRD Following HCT in ALL

27. Post-Transplant MRD in CLL

29. MRD and Outcomes in MM

30. MRD in Non-Hodgkin Lymphoma

33. Summary of MRD in Lymphoid Malignancies

34. Future Perspectives in MRD

35. Abbreviations

36. Abbreviations (cont)