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Turning off Neurotransmitters

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1 Turning off Neurotransmitters
Solomon H. Snyder  Cell  Volume 125, Issue 1, Pages (April 2006) DOI: /j.cell Copyright © 2006 Elsevier Inc. Terms and Conditions

2 Figure 1 Norepinephrine Inactivation
Norepinephrine is the key neurotransmitter in the sympathetic nervous system. In a trio of 1961 papers, Julius Axelrod showed that norepinephrine is inactivated through its reuptake into sympathetic nerve terminals. He subsequently showed that blockade of reuptake by drugs such as cocaine or the antidepressant imipramine potentiated norepinephrine activity in the sympathetic nervous system. Figure adapted from Axelrod's Nobel oration (Axelrod, 1971). Cell  , 13-15DOI: ( /j.cell ) Copyright © 2006 Elsevier Inc. Terms and Conditions

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