1. Adverse effect of paroxetine on sperm
Cigdem Tanrikut, M.D., Adam S. Feldman, M.D., Margaret Altemus, M.D., Darius A. Paduch, M.D., Ph.D., Peter N. Schlegel, M.D. 
Fertility and Sterility 
Volume 94, Issue 3, Pages (August 2010)
DOI: /j.fertnstert
Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

2. Figure 1
Semen parameters. Mean values for seminal volume, sperm concentration, percent total motility of sperm, and normal morphology are compared at baseline, week 2 of paroxetine, week 4 of paroxetine, and 1 month after discontinuation of paroxetine. There were no statistically significant differences (ANOVA).
Fertility and Sterility  , DOI: ( /j.fertnstert )
Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

3. Figure 2
Comparison of mean TUNEL scores. Mean percentage of sperm DNA fragmentation at baseline was 13.8%; this rose to 30.3% at week 4 of paroxetine administration (P < 0.001, t test).
Fertility and Sterility  , DOI: ( /j.fertnstert )
Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

4. Figure 3
TUNEL results with 30% threshold. Only 9.7% of patients had a TUNEL score ≥30% before medication compared with 50% of patients at week 4 of paroxetine (P=0.001, χ-square).
Fertility and Sterility  , DOI: ( /j.fertnstert )
Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

5. Figure 4
Changes in erectile function. Four questions (questions 3, 4, 5, 9) of the BSFI pertain to erectile function, rated on a scale of 0 (most severe dysfunction) to 4 (no dysfunction). The percentage of patients responding 0, 1, or 2 to the four questions increased significantly while taking paroxetine, from 3–6% to 30–41%. Erectile function returned to or approached baseline 1 month after cessation of medication (P < 0.003, χ-square).
Fertility and Sterility  , DOI: ( /j.fertnstert )
Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

6. Figure 5
Changes in ejaculatory function. Three questions (questions 6, 7, 10) of the BSFI assess ejaculatory function, rated on a scale of 0 (most severe dysfunction) to 4 (no dysfunction). The percentage of patients responding 0, 1, or 2 to the three questions increased significantly while taking paroxetine, from 3–9% to 30–56%. Ejaculatory function approached baseline 1 month after cessation of medication with only 9% of patients complaining of more than mild dysfunction (P ≤ 0.002, χ-square).
Fertility and Sterility  , DOI: ( /j.fertnstert )
Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions