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Patterns of responses in metastatic NSCLC during PD-1 or PDL-1 inhibitor therapy: Comparison of RECIST 1.1, irRECIST and iRECIST criteria  M. Tazdait,

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Presentation on theme: "Patterns of responses in metastatic NSCLC during PD-1 or PDL-1 inhibitor therapy: Comparison of RECIST 1.1, irRECIST and iRECIST criteria  M. Tazdait,"— Presentation transcript:

1 Patterns of responses in metastatic NSCLC during PD-1 or PDL-1 inhibitor therapy: Comparison of RECIST 1.1, irRECIST and iRECIST criteria  M. Tazdait, L. Mezquita, J. Lahmar, R. Ferrara, F. Bidault, S. Ammari, C. Balleyguier, D. Planchard, A. Gazzah, J.C. Soria, A. Marabelle, B. Besse, C. Caramella  European Journal of Cancer  Volume 88, Pages (January 2018) DOI: /j.ejca Copyright © 2017 Elsevier Ltd Terms and Conditions

2 Fig. 1 Kaplan–Meier overall survival estimates. In pink, conventional stable disease, partial and complete responses (n = 37); in green, true progressors (n = 103) and in orange, atypical responses (n = 20). CR, complete response; PR, partial response; SD, stable disease; atypical, atypical responses. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.) European Journal of Cancer  , 38-47DOI: ( /j.ejca ) Copyright © 2017 Elsevier Ltd Terms and Conditions

3 Fig. 2 Spider plot of pseudoprogressions (A; N = 8) and dissociated responses (B; N = 12). TP, time point; BL, baseline; Dissociated+, dissociated response with clinical benefit; Dissociated−, dissociated response with clinical benefit. European Journal of Cancer  , 38-47DOI: ( /j.ejca ) Copyright © 2017 Elsevier Ltd Terms and Conditions

4 Fig. 3 Representative imaging of two patients experiencing early PsPD. (A) PsPD of carcinomatous lymphangitis, peritoneal carcinomatosis and lung metastasis. (B) PsPD of carcinomatous lymphangitis and lung lesions. European Journal of Cancer  , 38-47DOI: ( /j.ejca ) Copyright © 2017 Elsevier Ltd Terms and Conditions

5 Fig. 4 Examples of two patients with dissociated responses. (A) Dissociated responses of adrenal, lung and peritoneal lesions. (B) Dissociated responses of adrenal, lymph node and lung lesions. European Journal of Cancer  , 38-47DOI: ( /j.ejca ) Copyright © 2017 Elsevier Ltd Terms and Conditions


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