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Fear of the Light or Need for Action: The IGL Will Judge

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Presentation on theme: "Fear of the Light or Need for Action: The IGL Will Judge"— Presentation transcript:

1 Fear of the Light or Need for Action: The IGL Will Judge
Ludovic S. Mure, Satchidananda Panda  Neuron  Volume 75, Issue 4, Pages (August 2012) DOI: /j.neuron Copyright © 2012 Elsevier Inc. Terms and Conditions

2 Figure 1 (A) The sequential expression of Ascl1, Helt, Tal1, and Sox14 in the rostral thalamus gives rise to the future IGL. While tangential migration from this pool establishes other SVS nuclei, ventral migration to the vLGN is limited by the expression of Dlx. In the Sox14-deficient mice, no progenitor migrates ventrally, increasing the density of Sox14 positive cells in the IGL. In the absence of Dlx1/2, Sox14 cells invade the vLGN, giving it an IGL-like phenotype. (B) In the wild-type mouse, the circadian clock (SCN) is entrained mainly by light information received directly from ipRGCs via the RHT and is influenced by photic and non-photic cues integrated at the level of the IGL. The IGL also participates in light modulation of activity, independent of the SCN clock. Both circadian- and light-modulation of activity determine diurnal activity pattern. In the Sox14-deficient mice, increased NPY+ cell density in the IGL promotes stronger inputs from the IGL on diurnal activity pattern. Neuron  , DOI: ( /j.neuron ) Copyright © 2012 Elsevier Inc. Terms and Conditions

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