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Baccoside A suppresses epileptic-like seizure/convulsion in Caenorhabditis elegans  Rakesh Pandey, Shipra Gupta, Sudeep Tandon, Olaf Wolkenhauer, Julio.

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Presentation on theme: "Baccoside A suppresses epileptic-like seizure/convulsion in Caenorhabditis elegans  Rakesh Pandey, Shipra Gupta, Sudeep Tandon, Olaf Wolkenhauer, Julio."— Presentation transcript:

1 Baccoside A suppresses epileptic-like seizure/convulsion in Caenorhabditis elegans 
Rakesh Pandey, Shipra Gupta, Sudeep Tandon, Olaf Wolkenhauer, Julio Vera, Shailendra K. Gupta  Seizure - European Journal of Epilepsy  Volume 19, Issue 7, Pages (September 2010) DOI: /j.seizure Copyright © 2010 British Epilepsy Association Terms and Conditions

2 Fig. 1 Structure of Baccoside A, a triterpenoid saponin from Bacopa monnieri Seizure - European Journal of Epilepsy  , DOI: ( /j.seizure ) Copyright © 2010 British Epilepsy Association Terms and Conditions

3 Fig. 2 Observations of seizures/convulsions in C. elegans. (A) Effect of temperature on the swimming behavior. (B and C) Alternating dorsal and ventral body bends pattern in normal swimming and seizure burst. (D) Seizures/convulsions behaviors with repeated unilateral contraction. (E) Continuous convulsions and paralytic body bend patterns. Seizure - European Journal of Epilepsy  , DOI: ( /j.seizure ) Copyright © 2010 British Epilepsy Association Terms and Conditions

4 Fig. 3 Effect of Baccoside A on seizure sensitivity and paralysis of C. elegans at 26–28±1°C. Error bar indicates the standard deviation. Seizure - European Journal of Epilepsy  , DOI: ( /j.seizure ) Copyright © 2010 British Epilepsy Association Terms and Conditions

5 Fig. 4 Effect of Baccoside A on seizure intensity in C. elegans at 26–28±1°C. Error bar indicates the standard deviation. Seizure - European Journal of Epilepsy  , DOI: ( /j.seizure ) Copyright © 2010 British Epilepsy Association Terms and Conditions


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