1. What Predicts Disability Progression in Multiple Sclerosis?

2. Overview: Prognostic Factors in MS

3. Clinical Prognostic Factors

4. Early Clinical Events Predict Disability Progression

5. MRI Prognostic Factors

6. Gray Matter Atrophy and Loss of Functional Connectivity

7. Multimodal EPs Predict Risk for Disability

8. OCT Alterations Predict Development of Disability

9. Neuronal Damage and Long-Term Synaptic Potentiation

10. LTP Compensation for Neuronal Damage

11. Predicting Response to Treatment

12. BENEFIT Study: Extent of Disease Activity Predicts Treatment Response

13. BENEFIT Study: Baseline Vitamin D Predicts Time to CDMS

14. MSCRG Study: Early Predictors of Long-Term Outcomes

15. MAGNIMS Network: Early Predictors of Short-Term Outcomes

16. Treating to Target NEDA

17. NEDA as a Predictor of Brain Atrophy and Optic Nerve Degeneration

18. CLIMB Cohort Study: Evolution of NEDA Over the Disease Course

19. NEDA as a Predictor of Long-Term Outcomes

20. Conclusions

21. Abbreviations

22. Abbreviations (cont)