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Modulating PCSK9 and the LDL Receptor: Tipping the Balance of Power

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Presentation on theme: "Modulating PCSK9 and the LDL Receptor: Tipping the Balance of Power"— Presentation transcript:

1 Modulating PCSK9 and the LDL Receptor: Tipping the Balance of Power

2 PRIMO: Observational Study in 7924 Patients

3 Genetics: PCSK9

4

5

6 PCSK9 Monoclonal Antibody vs Placebo on LDL-C Levels

7 Dosing and Administration

8 LAPLACE-TIMI 57: AMG 145 Q2W Dose Response -- Change in LDL-C From Baseline

9 Cholesterol Treatment Trialists Collaboration (N = 170,000)

10 Lipid-Lowering Goals: Back to Nature?

11 Impact of LDL-C on Plaque Progression

12 Global Assessment of Plaque Regression With a PCSK9 Antibody as Measured by Intravascular Ultrasound (GLAGOV)

13 PCSK9: Barriers

14 Large Unmet Medical Need

15 Thank you for participating in this activity
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