1. PET – POSITRON EMISSION TOMOGRAPHY

2. PET: POSITRON EMISSION TOMOGRAPHY

3. Most used PET radiotracers
Izot.
Radiotracer
Mecanism
18F
18F FDG (90%)
Glucidic Metabolism
18F-Fluoro-Dopa
dopaminergic Sintesys
18F-Fluoro-misonidazole
Tumoral Hipoxia
18F-Uracil (FU)
Chimioterapy evaluation (5FU)
18F FLT FluoroTimidin
Cellular Proliferation
15O
H²O15
Perfusion
11C
11C-Acetat
Oxidativ Metabolism (miocardic + tumoral)
11C-Palmitat
Miocardic Metabolism (acizi graşi)
11C-Tirozin
Tumoral Metabolism
11C-Timidin
Cellular Proliferation
11C-Metionin
11C-Colin
11C-Acid-Amino-IsoButiric
11C-Acid-Amino-Ciclopentan-Carboxilic (ACPC)
13N
13N-NH3 (amoniac)
Miocardial Perfusion
13N-Glutamat

4. Coincidence detection
Unstable nucleus
positron
antiparticle of the electron (same charge, opposite semn)
electron
positronium
2 gamma photons, 511 keV
Coincidence detection
(interval 10-9 sec.)
detector:
Bi germanat crystal(BGO)
Photomultipliers around
PET
principle

5. Desintegration through
Anihilation process
Anihilation
photon g
Anihilation
electron/positron b- b+
Anihilation
photon g
Desintegration through
positron emission
Device

7. PET: analogs metabolic
Glucidic Metabolism
Glicolisys in malignant cell
The germinating idea of PET:
Nobel Prize Medicine Laureat, Dr. Otto Warburg:
<The prime cause of cancer is the replacement of the respiration of oxygen by normal body cells by a fermentation of sugar>

8. GLUT transporters
GLUT8
GLUT6

9. 18FFDG (18F-2fluoro- 2deoxi-Dglucose)

10. PET Indication Miocardial Scintigraphy Tumoral Scintigraphy :
pulmonar neoplasm
mamary neoplasm
cerebral neoplasm
ovarian
gastrointestinal neoplasia
limphoma
Head-neck tumors
endocrin tumors : thyroidian, carcinoid, pheocromocitoma

11. Normal 18FFDG PET image

12. Normal PET and PET-CT images

13. Pathologic 18F FDG PET images in cancer

14. Lung cancer

15. Lung cancer with metastases

16. Hodgkin lymphoma with metastases

17. Melanoma

18. PET-CT images

19. Imagini PET (18FFDG), CT şi PET-CT normale (secţiuni coronale)

21. PET CT = PET-CT