2. Program Goals

3. Introduction

4. Program Outline

5. Patient-reported End-of-life Cancer Symptoms

6. Loss of Appetite Affects Survival

7. Effect of Weight Loss on Survival

8. Body Composition Changes in Cancer

9. Consequences of Cachexia

10. Definition and Classification of Cancer Cachexia An International Consensus

11. Ubiquitin-Proteasome System

12. Cachexia is Not Starvation

13. Program Outline

14. Parenteral Nutrition

15. Meta-analysis TPN for Cancer Patients Receiving Chemotherapy

16. Effect on Survival Oral Feeding for Malnourished Cancer Patients

17. Approach to the Patient With Cachexia

18. Megestrol Acetate Dosing

19. Megestrol Acetate vs Placebo Effect on Appetite

20. Megestrol Acetate Limitations

21. Despite Improvements in Appetite, Quality of Life Is Not Always Improved

22. Program Outline

23. New Avenues of Investigation for Treatment of Cancer-related Cachexia

24. Antimyostatin Agents

25. Antimyostatin Therapy Improvements in Body Weight and Survival

26. Example of Natural Myostatin Deficiency

27. Example of Natural Myostatin Deficiency (cont)

28. JAK Inhibition Associated With Weight Gain in Myelofibrosis Patients

29. Ruxolitinib for Treatment of Metastatic Pancreatic Cancer

30. Ghrelin Analogues Anamorelin for Treatment of Cancer Cachexia

31. Treatment With Anamorelin Improves Patient-reported Symptoms

32. Summary

33. Abbreviations

34. References

35. References (cont)

36. References (cont)

37. References (cont)

38. References (cont)