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Genetic Variants in Fanconi Anemia Pathway Genes BRCA2 and FANCA Predict Melanoma Survival
Jieyun Yin, Hongliang Liu, Zhensheng Liu, Li-E. Wang, Wei V. Chen, Dakai Zhu, Christopher I. Amos, Shenying Fang, Jeffrey E. Lee, Qingyi Wei Journal of Investigative Dermatology Volume 135, Issue 2, Pages (February 2015) DOI: /jid Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions
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Figure 1 Kaplan–Meier survival analysis.For cutaneous melanoma (CM) overall survival (OS; a) by 0, 1, 2, and 3/4 number of unfavorable genotypes (NUG) (i.e., rs AG, rs CC, rs CC, and rs TT) and (b) by 0–1 and 2–4 NUG; for CM MSS (c) by 0, 1, 2, and 3/4 NUG and (d) by 0–1 and 2–4 NUG. Journal of Investigative Dermatology , DOI: ( /jid ) Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions
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Figure 2 Receiver operating characteristic (ROC) curves for prediction of cutaneous melanoma (CM) survival.(a) Five-year overall survival (OS) rate and (b) five-year melanoma-specific survival (MSS) rate, based on tumor stage and thickness, tumor stage, Breslow thickness plus NUG. Journal of Investigative Dermatology , DOI: ( /jid ) Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions
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Figure 3 Upregulation of BRCA2 (a, b) and FANCA (c, d) in the progression of melanoma.The y axis is a score representing the expression levels of BRCA2 and FANCA. Journal of Investigative Dermatology , DOI: ( /jid ) Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions
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Figure 4 Single-nucleotide polymorphism (SNP)–gene expression associations.Analyses of BRCA2 expression levels by genotypes of (a) rs , (b) rs206118, (c) rs , and (d) combined risk genotypes (i.e., rs CC, rs AG, and rs CC) in 270 HapMap lymphoblastoid cell lines from all population. The number of individuals with missing data for rs , rs206118, and combined risk genotypes was 2, 2, and 4, respectively. The y axis is the normalized gene expression level. Journal of Investigative Dermatology , DOI: ( /jid ) Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions
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