1. Opening Activity: May 29, 2018 Make a TITLE Page for “Inheritance”
Under the title make a goal for yourself for this unit.
Create an “Opening Activities Page” (1 page will be fine, it’s only 7 days.)
If you don’t have any space – Make a packet of yellow paper – about pages. – See RESOURCE TABLE
I can… make an initial model of inheritance of sickle cell disease
Homework:
CVR due 5/30
Inheritance Initial Model

2. How has sickle cell disease impacted Shaniya?
Meet Shaniya
How has sickle cell disease impacted Shaniya?
How does Shaniya deal with sickle cell disease?
What happens to sickle cell patients as they get older?
What questions do you have about Shaniya’s family?

3. Class Observations

4. How does a potentially fatal disease persist in a population?
One idea: one slip of paper
Your biggest question on another slip of paper
Crumple them up and put them in the appropriate bowl
Idea #1
Big question

5. Idea Grouping
Everyone gets one idea from the bowl and reads it silently
One person reads an idea out loud and starts a pile
Idea #1
My paper says…

6. That’s similar to my idea because…
3. Others raise hands if idea is similar and share those ideas. 4. Idea #2 is added to the pile with Idea #1
That’s similar to my idea because… #2
Idea #1
Idea #2
Idea #1

7. 5. Continue until all ideas related to first idea are shared 6
5. Continue until all ideas related to first idea are shared 6. Start again with a new starting idea
Idea #2
Me too!
Idea #1
Idea #3 #3
My idea is different… #2 #1 #4 #4 #3

8. 7. Repeat until all ideas are shared and categorized 8
7. Repeat until all ideas are shared and categorized 8. Come up with a caption for each idea
Idea #5
Idea #6
These ideas say…
These ideas say…
Idea #4
Idea #2
Idea #1
Idea #3

9. Match the questions with the below categories! (pd 4)
Passed on from parent to child
Benefits of disease
Genetic mutations
Cures/Dealing with Sickle Cell
Facts about sickle Cell
Other modes of inheritance.

10. Match the questions with the below categories! (pd 3)
Gene Regulation/Proteins Made
Cure/How it adapts
Benefits of Sickle Cell
Cell Division
Living with Sickle Cell
Passed down through generations

11. Match the questions with the below categories! (pd 5)
Disease is caused by genes or chromosomes.
Disease is spread by blood/infections
Disease is caused by zodiac signs/external forces.
Growing and dividing
Sickle Cells is passed down from parent to child.
Gene regulation turns on sickle cell or it was dormant.

12. Initial Models Draw zoom bubbles to show what you think is going on.
Remember what you know about genes, proteins, and gene regulation
What questions do you have?

13. Opening Activity: May 30, 2018
I will Stamp CVR and Inheritance Initial Model.
Copy the following grid onto you paper. Reflect on processes we have studies so far this year and fill out the grid.
Scale
Processes
Atomic- Molecular
Microscopic
Macroscopic
Large Scale
I can… explain what is happening in Shaniya’s genes.
Homework:
Retake Test Corrections due June 5th.
Test Retake 6/7, 6/8 & 8am.
Inheritance Quiz Friday June 15th

14. Gene Regulation Test
Test is out of 26, rather than 27. I took off one point on question #8. It is out of 3 pts, not 4. If you got all 4 pts, congrats, you got extra credit! A
% Top Retake Grade B C D
If you want to retake you must follow the directions:
MUST do Test Corrections and turn in by Tuesday June 5th.
Sign up for retake time – on clipboard available June 5th.
Come take the retake test:
Thursday June 7th 8:00am
Friday June 8th 8:00am
Tuesday June 12th 8:00am

15. Initial Models Draw zoom bubbles to show what you think is going on.
Remember what you know about genes, proteins, and gene regulation
What questions do you have?

16. How is it determined if a person has sickle cell disease or trait?
Normal Blood Cells
No problem!
Sickle Cell Disease
1 in 365 African American Births
Can kill if not treated
Sickle Cell Trait
1 in 13 African American Births
Usually no symptoms

17. “Roundbuds”

18. Roundbud colors White molecule Red Pigment molecule Enzyme Q

19. Cell with gene for non-functional enzyme Q
Cell of RED flower
Cell of WHITE flower
Non-functional gene
Functional gene
Cell with gene for non-functional enzyme Q
Cell with gene for functional enzyme Q

20. Chromosomes come in PAIRS
Matching chromosomes (homologs or homologous chromosomes): one from your mom (maternal) and other from your dad (paternal).

21. Chromosomes come in pairs
Pink represents chromosomes from mother
Blue represents chromosomes from father

22. Remember cell differentiation
Remember cell differentiation? The function of a cell is determined by the genes that are expressed in a cell.
If the highlighted genes are expressed, what type of cell will this be?
ATP synthase enzyme
Actin Protein
Lactase Enzyme
Keratin Protein
Osteoblast Enzyme
Facilitator Protein ? =

23. There are actually TWO versions of that chromosome
Chromosomes come in PAIRS!
From Mother
From Father
ATP synthase enzyme
Actin Protein
Lactase Enzyme
Keratin Protein
Osteoblast Enzyme
Facilitator Protein
ATP synthase enzyme
Actin Protein
Lactase Enzyme
Keratin Protein
Osteoblast Enzyme
Facilitator Protein

24. Pair of chromosomes means you get two versions of each gene
From Mother
From Father
Sickle cell anemia gene
Sickle cell anemia gene

25. Version of gene = Allele
Can have different versions of genes
These are different “alleles”

26. Two alleles (versions) for Hemoglobin B protein
From Mother
From Father
Non-functional allele for Hemoglobin B
Functional allele for Hemoglobin B

27. Draw the enzymes and molecules present in the cells of each type of bioflower below.
= functional
= non-functional
Type 1
1 from mom
2 mom
1 from dad
2 dad
nucleus

28. Draw the enzymes and molecules present in the cells of each type of bioflower below.
= functional
= non-functional
Type 2 2A Y1 1A 2B 1B
nucleus

29. Draw the enzymes and molecules present in the cells of each type of bioflower below.
= functional
= non-functional
Type 3 2A 1A 2B 1B
nucleus

30. Opening Activity: May 31, 2018
Explain how it would be possible for a cell to have both functional and non-functional proteins in the same cell.
If you need to retake the test, retake tickets are available at the front table – they are due Tuesday June 5th if you’d like to retake the test.
Pick up Idea Journal at front table – name & tape in
I can… Explain Shaniya’s genes. Explain how proteins fold in sickle cells.
Homework:
Retake Test Corrections due June 5th.
Test Retake 6/7, 6/8 & 8am.
Inheritance Quiz Monday June 11th

31. Functional, Functional Non-functional, Non-functional
The combination of alleles determines the observed characteristics
functional
allele
non-functionalallele
non-functionalallele
functional
allele
functional
allele
non-functionalallele
Chromosome
combination
Allele
combination
Functional, Functional
Functional,
Non-functional
Non-functional, Non-functional
Which combinations produce red?
Which combinations produce blue?
Observed
characteristic
RED
RED
BLUE

32. The combination of alleles determines the observed characteristics
RED
allele
RED
allele
BLUE
allele
RED
allele
BLUE
allele
BLUE
allele
Chromosome
combination
Allele
combination
red, red
red, blue
(or blue, red)
blue, blue
Which combinations produce red?
Which combinations produce blue?
Observed
characteristic
RED
RED
BLUE

33. How many red alleles do you need for a red flower?
BLUE
allele
RED
allele
BLUE
allele
BLUE
allele
Chromosome
combination 1
Allele
combination
red, red
red, blue
(or blue, red)
blue, blue
Which combinations produce red?
Which combinations produce blue?
Observed
characteristic
RED
RED
BLUE

34. How many alleles do you need for a blue flower?
RED
allele
RED
allele
BLUE
allele
RED
allele
BLUE
allele
BLUE
allele
Chromosome
combination 2
Allele
combination
red, red
red, blue
(or blue, red)
blue, blue
Which combinations produce red?
Which combinations produce blue?
Observed
characteristic
RED
RED
BLUE

35. Dominant and Recessive alleles1
Only need allele to show trait =
DOMINANT
Need alleles to show trait =
RECESSIVE 2
Could have students write the rule first before giving this slide with the answer
Both copies of the color gene need to be the blue allele for the flower to look blue.
Flowers only look blue when both copies of the color gene are the blue allele.

36. Use CAPITAL letters to represent DOMINANT allele
Use lowercase letters to represent recessive allele r
RED
allele R
BLUE
allele
NOTE! They are BOTH the letter R! Usually use the first letter of the word that represents the dominant trait.

37. The combination of alleles determines the observed characteristics
RED
allele
RED
allele
BLUE
allele
BLUE
allele
RED
allele
BLUE
allele
Chromosome
combination
Allele
combination
red, red
red, blue
(or blue, red)
blue, blue
Which combinations produce red?
Which combinations produce blue?
Observed
characteristic
RED
RED
BLUE

38. The combination of alleles determines the observed characteristics
Chromosome
combination
Allele
combination RR Rr rr
Which combinations produce red?
Which combinations produce blue?
Observed
characteristic
RED
RED
BLUE

39. Phenotype – what you SEE (the observed trait)
Genotype – the allele combination
(the genes)
Example: Trait = “flower color”
Phenotype = “RED” or “BLUE”
Genotype = “RR” or “Rr” or “rr” R

40. The combination of alleles determines the observed characteristics
Chromosome
combination
Allele
combination RR Rr rr
Which combinations produce red?
Which combinations produce blue?
Observed
characteristic
RED
RED
BLUE

41. The combination of alleles determines the observed characteristics
Chromosome
combination
GENOTYPE RR Rr rr
Which combinations produce red?
Which combinations produce blue?
PHENOTYPE
RED
RED
BLUE

42. RR rr Rr Homozygous – the two alleles are the same
Heterozygous – the two alleles are different Rr

43. Check -in– with your group
Use your understanding of bioflowers to determine the genotypes of individuals with these phenotypes:
Phenotype
Normal Cells
Sickle Cell Trait
SC Disease
Chromosomes
Genotype SS Ss ss

44. How do proteins fold in a person with sickle cell disease?
Procedure:
Complete question #1 journal or worksheet.
Only write the differences in DNA.
USE CODON wheel to note the amino acid dif.
Complete Venn diagram to compare HbA and HbS.
Read about the amino acids and sketch them out, answering #2 and #3.
Use the four types of hemoglobin molecules & string circles to create cells and complete table.

45. Opening Activity: June 1, 2018
Work Time on Idea Journal (15 min)
Movie:  Cracking the Code (answer pre questions first)
Cracking the Code - Movie Link
HW:  Inheritance Idea Journal - Allele and Chromosomes Notes - Due 6/4
I can… Complete idea journal for chromosomes and alleles.
Homework:
Retake Test Corrections due June 5th.
Test Retake 6/7, 6/8 & 8am.
Inheritance Quiz Monday June 11th