1. Genome sequencing informatics
Gabor T. Marth
Department of Biology
Boston College
Chestnut Hill, MA 02467

2. Genome sequence
the complete genome sequence contains (almost) all information carried by the chromosomes
the primary template on which to outline functional features of our genetic code (genes, regulatory elements, secondary structure, tertiary structure, etc.)

3. Completed genomes
~3,000 Mb
>100 Mb
~100 Mb
~1 Mb

4. Sequencing strategies
Whole-genome shotgun sequencing
Clone-based shotgun sequencing

5. Sequencing software tools
PHRED
PHRAP
CONSED, AUTOFINISH