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Cardiac Biomarkers.

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Presentation on theme: "Cardiac Biomarkers."— Presentation transcript:

1 Cardiac Biomarkers

2 Cost of Heart Failure to Society

3 Biomarkers in the Management of Heart Failure Challenges and Opportunities

4 BNP and NT-proBNP for Diagnosis or Exclusion of Heart Failure

5 Correlations of Natriuretic Peptides With Cardiac Structure and Function

6 The Differential Diagnosis of an Elevated BNP or NT-proBNP

7 BNP and NT-proBNP for Prognosis in Heart Failure

8 Biomarker-Guided Heart Failure Trials

9 Understanding Heterogeneous Results in “Guided Therapy” Trials

10 TIME CHF Cost-Effectiveness BNP-Guided Therapy

11

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13 Dallas Heart Study

14 High-Sensitivity Troponin Use in Europe

15 Troponins and Risk Stratification in Stable Outpatient CAD

16

17 Secondary Prevention and Prognostic Value of High-Sensitivity Troponins

18 Biomarker Assessments in Stable Patients With T2DM Observations From the SAVOR-TIMI 53 Trial

19 ADVANCE Trial

20 Cardiovascular Mortality Risk According to Number of Elevated Biomarkers

21 Additive Value of ST2 to NT-proBNP in Long-Term Prognosis

22 Prognosis Value of BNP/NT-proBNP Based on Timing of Measurement During Index Hospitalization for Acute HF

23 Therapies That Affect B-Type Natriuretic Peptide Levels

24 Neprilysin Inhibition A New Paradigm for HF Care?

25 LCZ696 and Biomarkers

26 Biomarkers and Risk Assessment

27 AMI

28 6 Million Chest Pain Visits Evaluated Annually in the United States

29 Can We Do Better?

30 Three Clinical Evaluation Tools

31 APACE hs-cTnT 1-Hour Algorithm

32 Patient Inclusion/Exclusion Criteria

33 TRAPID-AMI Results Presented at ESC 2014

34 Clinical Implications

35 Could Older Adults Be at Greater Risk of a “False Positive” Diagnosis of AMI?

36 Key Clinical Points

37 References

38 References (cont)

39 References (cont)

40 References (cont)

41 References (cont)


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