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Pharmacodynamics of amoxicillin/clavulanic acid against Haemophilus influenzae in an in vitro kinetic model: a comparison of different dosage regimens.

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Presentation on theme: "Pharmacodynamics of amoxicillin/clavulanic acid against Haemophilus influenzae in an in vitro kinetic model: a comparison of different dosage regimens."— Presentation transcript:

1 Pharmacodynamics of amoxicillin/clavulanic acid against Haemophilus influenzae in an in vitro kinetic model: a comparison of different dosage regimens including a pharmacokinetically enhanced formulation  E. Löwdin, O. Cars, I. Odenholt  Clinical Microbiology and Infection  Volume 8, Issue 10, Pages (October 2002) DOI: /j x Copyright © 2002 European Society of Clinical Infectious Diseases Terms and Conditions

2 Figure 1 The concentration of amoxicillin in the in vitro kinetic model corresponding to a dose of 875 mg b.i.d. (♦), 500 mg t.i.d. (▪) and of the pharmacokinetically enhanced formulation 2000 mg b.i.d. (▴). Clinical Microbiology and Infection 2002 8, DOI: ( /j x) Copyright © 2002 European Society of Clinical Infectious Diseases Terms and Conditions

3 Figure 2 The rate and extent of killing of amoxicillin/clavulanic acid at a concentration corresponding to a dose of 875/125 mg b.i.d. (▪) and 500/125 mg t.i.d. (♦) against H. influenzae LH 2803 in the in vitro kinetic model (mean ± SD). Clinical Microbiology and Infection 2002 8, DOI: ( /j x) Copyright © 2002 European Society of Clinical Infectious Diseases Terms and Conditions

4 Figure 3 (a) The rate and extent of killing of amoxicillin/clavulanic acid at a concentration corresponding to a dose of 875/125 mg b.i.d. against the clinical strains of H. influenzae in the in vitro kinetic model (mean ± SD). (b) The rate and extent of killing of amoxicillin/clavulanic acid at a concentration corresponding to a dose of 500/125 mg t.i.d. against the clinical strains of H. influenzae in the in vitro kinetic model. Clinical Microbiology and Infection 2002 8, DOI: ( /j x) Copyright © 2002 European Society of Clinical Infectious Diseases Terms and Conditions

5 Figure 4 The rate and extent of killing of amoxicillin/clavulanic acid simulating the slow-release compound against H. influenzae LH 2803 and the clinical strains of H. influenzae in the in vitro kinetic model (mean ± SD). Clinical Microbiology and Infection 2002 8, DOI: ( /j x) Copyright © 2002 European Society of Clinical Infectious Diseases Terms and Conditions


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