1. Unraveling the Role of PD-1/PD-L Interactions in Persistent Hepatotropic Infections: Potential for Therapeutic Application? 
Henry Radziewicz, Holly L. Hanson, Rafi Ahmed, Arash Grakoui 
Gastroenterology 
Volume 134, Issue 7, Pages (June 2008)
DOI: /j.gastro
Copyright © 2008 AGA Institute Terms and Conditions

2. Figure 1
T-cell responses modified by PD-1/PD-L1 interactions in the liver. When inflammation is minimal, there is limited expression of PD-1 on T cells and PD-L1 on hepatocytes. TCR signaling provokes vigorous cytokine production and T-cell proliferation (left). With increased inflammation, there is enhancement of PD-1/PD-L1 co-inhibitory signaling and impairment of cytokine production and proliferation of responding T cells (center). At maximal levels of inflammation, there is increased signaling through PD-1 following PD-L1 ligation enhancing apoptosis of responding T cells (right).
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2008 AGA Institute Terms and Conditions