1. Agenda 7:30pm Welcome M. Everitt/R. Chinnock/J. Alejos 7:40pm
Steering Committee Update
Melanie Everitt
7:45pm
DCC Update
James Kirklin
8:00pm
Database Committee Report
Marc Richmond
8:15pm
Foundation Update
Craig Collum
8:30pm
DISCUSSION
Research Project Timeline of Submission
Progression of Elections
8:55pm
Pedimacs Update
Betsy Blume
9:10pm
Scientific Committee Report
Anne Dipchand
9:20pm
New Officers and New Business
9:30pm
Adjourn

2. 2017 Scientific Committee Members
Anne Dipchand, MD (2018)
Chair
Elfi Pahl, MD (2018)
Vice Chair/Secretary &
Scientific-Steering
Committee Liaison
Members At Large
Simon Urschel, MD (2017)
Dan Bernstein, MD (2017)
Charlie Canter, MD (2017)
Matthew Fenton, MD (2017)
Janet Scheel, MD (2017)
Rocky Singh, MD, MS (2017)
Scott Auerbach, MD (2018)
Jennifer Conway, MD (2018)
Ashwin Lal, MD (2018)
Jacque Lamour, MD (2018)
Bob Shaddy, MD (2018)
Steve Webber, MD (2018)
James Kirklin, MD
Elizabeth Pruitt, MSPH

3. Submitted Manuscripts Status: November 2017
Topic
PI/SRI
Journal
VAD
(AHA 2012)
Dipchand
Kirklin
JACC
PTLD
(ISHLT 2014)
West
Feingold
JHLT
LDS: Surveillance Biopsies
(ISHLT 2016)
Zinn
Canter
Pediatric Transplantation
AE VAD
(ISHLT 2017)
Sutcliffe
Blume

4. Manuscripts in Preparation Status: November 2017
Topic
PI/SRI
Status
MCSD Graft Failure
(ISHLT 2016)
Simmonds
Addonizio
Dr. Simmonds to finalize manuscript with UAB
Single Ventricle in MCSD
Das
Kirklin
Dr. Das to finalize manuscript with UAB
Diabetes Post-Transplant
(AHA 2016)
Sparks
Morrow
Dr. Sparks to finalize manuscript with UAB

5. Manuscripts in Preparation Status: November 2017
Topic
PI/SRI
Status
<10 kg
(ISHLT 2017)
Conway
Pahl
Dr. Conway to finalize manuscript with UAB
Fontan
Dykes
Almond
Dr. Dykes to finalize manuscript
Berlin Heart
Jeewa
Fraser
Dr. Jeewa to finalize manuscript with UAB
LDS: HLA
Albers
Law
Dr. Albers to finalize manuscript
Pulmonary Atresia
(AHA 2017)
Joong
Gajarski
Dr. Joong to finalize manuscript with UAB
Hemodynamic Surveillance
Arbon
Kindel
Dr. Arbon to finalize manuscript with UAB

6. Abstracts Submitted to ISHLT 2018
Topic
PI/SRI
Status
Heterotaxy
Khan
Everitt
Abstract submitted
Renal Dysfunction
(Pedimacs Linkage)
Hollander
Conway
VAD Infection
Auerbach
Kirklin
LDS: HC Rejection
Kleinmahon
Practice Variation Group: Surveillance Biopsy
Godown
Hsu
Practice Variation Group:
Surveillance Angiography
Pahl
Chin

7. Publications: May 2017 – November 2017

8. Recent Publications
American Journal of Transplantation, Volume 17, Issue 6, June 2017, Pages 1525–1539

9. Recent Publications
The Journal of Heart and Lung Transplantation  Volume 36, Issue 9, September 2017, Pages 996–1003

10. Recent Publications
European Heart Journal, Volume 38, Issue 38, October 2017, pages

11. Recent Publications: In Press
The Journal of Heart and Lung Transplantation, Accepted May In Press

12. Recent Publications: In Press
Pediatric Transplantation, Accepted October 2017, In Press
The Impact of Flow PRA on Outcome in Pediatric Heart Recipients in Modern Era: An Analysis of the Pediatric Heart Transplant Study Database
Das B. B., MD,a Pruitt E., MSPH,b Molina K., MD,c Ravekes W., MD,d Auerbach S., MD,e Savage A., MD,f Knox L., RN, BSN, CCTC,g Kirklin J. K., MD,b Naftel D.C., PhD,b Hsu D., MD;h on behalf of the Pediatric Heart Transplant Study Investigators
Abstract
Data from patients in the Pediatric Heart Transplant Study (PHTS) registry transplanted between 2010 and 2014 were analyzed to determine the association between HLA antibody (PRA) determined by solid phase assay (SPA) using Luminex or flow cytometry with a positive retrospective crossmatch and the post-transplant outcomes of acute rejection and graft survival. A total of 1459/1596 (91%) recipients had a PRA reported pre-transplant; 26% had a PRA >20%. Patients with a PRA>20% were more likely to have congenital heart disease, prior cardiac surgery, extracorporeal membrane oxygenation support at listing, and waited longer for transplantation than patients with a PRA <20%. Patients with higher PRA% determined by SPA were predictive of a positive retrospective crossmatch determined by flow cytometric method (p<0.001). A PRA >50% determined by SPA was independently associated with worse overall graft survival after first month of transplant in both unadjusted and adjusted for all other risk factors. In this large multicenter series of pediatric heart transplant recipients, an elevated PRA determined by SPA remains a significant risk factor in the modern era.

13. Presentations at AHA

14. Amy C. Rothkopf3, James K. Kirklin2, and Robert J. Gajarski7
AHA 2017 Rapid-Fire Oral Presentation Monday, November 13, 10:10am – 11:20am Clinical III Forum, Science and Technology Hall
Outcomes of Infants with Pulmonary Atresia with Intact Ventricular Septum Listed for Cardiac Transplantation: A Multi-Institutional Study
Anna Joong1, Elizabeth Pruitt2, Warren A. Zuckerman3, James W. Blackston2, Rebecca K. Ameduri4, Juan C. Alejos5, Gerard J. Boyle6,
Amy C. Rothkopf3, James K. Kirklin2, and Robert J. Gajarski7
1Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL; 2University of Alabama at Birmingham, Birmingham, AL; 3Columbia University-Morgan Stanley Children's Hospital of New York Presbyterian, New York, NY; 4University of Minnesota Masonic Children's Hospital, Minneapolis, MN; 5Mattel Children’s Hospital, Los Angeles, CA; 6Cleveland Clinic Foundation, Cleveland, OH; 7Naionwide Children's Hospital, Columbus, OH.

15. AHA 2017 Poster Presentation Tuesday, November 14, 1:30pm – 2:45p Clinical Section, Science and Technology Hall
Are Routine Surveillance Invasive Hemodynamics Obtained Post-Transplant Useful in Pediatric Heart Transplant Recipients?
Kate S. Arbon1, Yuk M. Law1, James K. Kirklin2, Elizabeth Pruitt2, Kenneth O. Schowengerdt3, Timothy M. Hoffman4, Thomas J. L’Ecuyer5, and Steven J. Kindel6
1Seattle Children’s Hospital, Seattle, WA; 2University of Alabama at Birmingham, Birmingham, AL; 3Cardinal Glennon Children's Medical Center, St. Louis, MO; 4University of North Carolina, Chapel Hill, NC; 5University of Virginia Medical Center, Charlottesville, VA; 6Children's Hospital of Wisconsin, Milwaukee, WI

16. Annual Fall Meeting, November 12, 2017
PHTS Working Groups
Group 1: Immunosuppression Protocols
Marc Richmond, MD, MS
Group 2: Diagnoses of cellular rejection and surveillance 
Daphne Hsu, MD
Group 3: Diagnosis and treatment of CAV
Elfi Pahl, MD

17. Practice Variation Workgroups
Group 1: Immunosuppression Protocols
Proposing revision of Initial Immunosuppression data collection form (Form 3)
Examined era effect of medications

18. Practice Variation Workgroups
Group 2: Diagnosis of Cellular Rejection and Surveillance
Abstract submitted to ISHLT 2018
Examined center variability within first year and after first year of transplant
Surveillance practices
Diagnosis practices
Recipient age related practices
Preparing manuscript

19. Practice Variation Workgroups
Group 3: Diagnosis and Treatment of CAV
Abstract submitted to ISHLT 2018
Examined center variability for coronary evaluation methods
Surveyed centers about angiography frequency
Preparing protocol guidelines