1. CBC findings

2. Asymptomatic to life-threatening
Classic symptoms:
Anemia: fatigue, pallor, dyspnea
Neutropenia: infection, fever, sore throat
Thrombocytopenia: ecchymoses, bleeding
In sever cases

3. Normal WBC count Leukocyte: (4.3 – 10.8) 109/L Neutrophils: 45% – 74%
Bands: 0-4%
Lymphocytes: 16% - 45%
Monocytes: 4% - 10%
Eosinophils: 0 – 7%
Basophils: 0 – 2%

4. Anemia
Anemia is most often recognized by abnormal screening laboratory tests.

5. Anemia
Anemia
(M:HCT<40)→RBC indices→82<MCV<98
(F:HCT<38)

6. Platelets Released from megakaryocyte Normal count: 150,000 – 450,000
Major regulator: Thrombopoietin which synthesized in the liver
Synthesis is increased with inflammation
Thrombocytopenia: PLT< 150,000
هاریسون

7. ترومبوسیتوپنی شغلی بیشتر به صورت آنمی آپلاستیک دیده میشود تا ترومبوسیتوپنی ایزوله.
لادو

8. Toxic agent Use Mechanism
Isolated thrombocytopenia
Toxic agent
Use
Mechanism
TDI
Polimerizing agent
Immune
Pyretrin
Lindane
DDT
Insecticide
Megakaryocyte hypoplasia
Turpentine
Organic solvent
Vinyl chloride
Plastics
Liver insufficiency with hypersplenism

9. Algorythm
هاریسون

10. Other PLT disorders
Functional disturbances of platelets, as seen with various drugs & metabolic disturbances, have not been described in relation to specific environmental agents or exposures.

11. Similarly, no agent is known to cause thrombocytosis or hypercoagulable states.
Except in the setting of a primary marrow disorders or injury to another organ system, such as in lung cancer.

12. Thanks for your attention