1. Deoxyribonucleotide production
Title slide.

2. A) Model of the enzyme; b) a ribbon diagram of R2 Fe III is orange, tyr 122 has green Cs and red Os, c) the binuclear Fe III, and d) a ribbon diagram of the R1 subunit.

3. Another representation of the ribonucleotide reductase model.

4. The reaction sequence.

5. The overall reaction is the reduction of 2’ OH.

6. The reactions of the -SHs.

7. E. coli thioredoxin.

8. Ribbon diagram of a 320-residue subunit of the homodimeric E
Ribbon diagram of a 320-residue subunit of the homodimeric E. coli thioredoxin reductase.

9. Glutathione, glutathione reductase.

10. Thioredoxin reductase involvement.

11. Another representation.

12. The control network for controlling ribonucleotide reductase.

13. The reponse to high [ATP].

14. Thymidylate synthase and inhibitory sites.