1. Table. Clinical Efficacy and Safety
Ticagrelor
Clopidogrel
HR (95% CI)
Interaction P-value
CV death, MI, or stroke
≥ 75 years
17.2
18.3
0.95 (0.78–1.13)
0.22
<75 years
8.6
10.4
0.82 (0.74–0.91)
All-cause mortality
9.8
12.4
0.81 (0.65–1.03)
0.78
3.6
4.8
0.78 (0.67–0.92) MI
9.3
9.4
0.96 ( )
0.25
5.4
6.6
0.81 ( )
CV death
8.1
10.3
0.79 ( )
0.90
3.3
4.2
0.81 ( )
Definite stent thrombosis
1.8
2.1
0.66 (0.3–1.45)
0.94
1.3
1.9
0.67 (0.49–0.93)
Overall major bleeding
14.2
13.5
1.04 (0.84–1.28)
1.00
11.2
10.8
1.04 (0.94–1.15)
Non-CABG major bleeding
8.3
7.1
1.16 (0.87–1.55)
3.9
3.2
1.22 (1.02–1.46)