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Patterns of Inheritance
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Dominance One copy of a gene is enough for a trait to show. In heterozygotes, the dominant trait shows, not the recessive. 2 Phenotypes: Dominant (H) and recessive (h) Examples: Huntington’s Disease Achondroplasia (dwarfism) Tongue Rolling
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Dominance h h H H h H h h h h h h
A man who is heterozygous for Huntington’s Disease marries a normal woman. What is the chance that their offspring will have the disease? h h H H h H h h h h h h
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Recessiveness Trait only shows if there are no dominant alleles. Heterozygotes have the dominant phenotype. 2 Phenotypes: Dominant (H) and recessive (h) Examples: Albinism Cystic Fibrosis Hitchhiker’s Thumb
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Recessiveness f f F F f F f F F f F f
A woman with cystic fibrosis wants to minimize her chances of passing the disease to her children. Which genotype of man would be best for producing children without the disease? f f F F f F f She should marry a man Who is homozygous, FF For the normal allele. He Would not be a carrier, But all their kids would be. F F f F f
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Codominance Two alleles are both dominant. When they occur together, both phenotypes show up completely, without blending. 3 Phenotypes CC, CS, SS Examples: Sickle Cell Roan cattle Erminette chickens
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Codominance A black chicken is crossed with an erminette chicken. What ratio of feather colors would be expected in the offspring? B W B B B B W B B B B W
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Incomplete Dominance Neither of two alleles are completely dominant. In a heterozygote, both traits show up, but their effects are blended. 3 Phenotypes RR, RW, WW Examples: Hair curliness Snapdragons
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Incomplete Dominance A curly haired woman and a straight haired man have a baby. What must be the hair texture of their child? C C S C S C S All babies will have wavy hair, CS (half- way between curly snd straight. S C S C S
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Sex-linked Gene controlling the trait is located on the X chromosome (also called X-linked). Males are affected more often than females 4 Phenotypes XHXH, XhXh, XHY, XhY Examples: Red-green Colorblindness Hemophilia Male-pattern baldness
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Sex-linked A man with hemophilia marries a woman who is a carrier for the disease, what percent of their sons will have hemophilia? Xh Y XH XH Xh Y XH 50% of the males (shaded green) would have hemophilia. Xh Xh Xh Y Xh
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Multiple Alleles More than two alleles control a single trait. There may be any combination of dominant or recessive alleles. The number of phenotypes can vary, but is usually greater than 3. Examples: Blood type Alleles IA, IB, and i
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Multiple Alleles A woman with AB blood (IAIB) gave birth to a baby with AB blood. Could a type O man (ii) be the baby’s father? i i IA IA i i IA No, the father could not have type O blood. IB IB i i IB
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Polygenic Traits Multiple genes control a single trait.
Could be any number of phenotypes, but usually a large number. Examples: Eye color Hair color Skin color Baby weight
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Polygenic You will NEVER see a Punnett Square for a polygenic trait. They exist, but they are very complicated.
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Polygenic Instead, you will see what we call a bell curve, which shows the number of people with each level of the trait.
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