1. Positioning NK-κB in multiple myeloma
by Bernard Klein
Blood
Volume 115(17):
April 29, 2010
©2010 by American Society of Hematology

2. The main gene abnormalities targeting NF-κB pathway are displayed in red and italic font.
The main gene abnormalities targeting NF-κB pathway are displayed in red and italic font. They result in aberrant activation of noncanonical and canonical NF-κB pathway that together with other signaling pathway activation (JAK/STAT, MAP kinase, PI3K/AKT) trigger myeloma cell survival, proliferation and drug resistance.
Bernard Klein Blood 2010;115:
©2010 by American Society of Hematology