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Of Worms and Men: HLH-30 and TFEB Regulate Tolerance to Infection

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1 Of Worms and Men: HLH-30 and TFEB Regulate Tolerance to Infection
George R. Tiller, Danielle A. Garsin  Immunity  Volume 40, Issue 6, Pages (June 2014) DOI: /j.immuni Copyright © 2014 Elsevier Inc. Terms and Conditions

2 Figure 1 HLH-30 (TFEB) Modulates an Evolutionarily Conserved Transcriptional Immune Response Activated HLH-30 (TFEB) translocates to the nucleus to upregulate genes with different functions. The stimuli and upstream signaling component(s) necessary to activate the HLH-30 (TFEB)-directed transcriptional immune response are currently unknown. mTORC1 is involved in mediating TFEB activation in response to nutritional stress (Settembre et al. 2012), but its role in immune response has not been established. Immunity  , DOI: ( /j.immuni ) Copyright © 2014 Elsevier Inc. Terms and Conditions


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