1. Advances in the Molecular Diagnosis of Hepatitis C and Their Clinical Implications 
Jeffrey J. Germer, BS, Nizar N. Zein, MD 
Mayo Clinic Proceedings 
Volume 76, Issue 9, Pages (September 2001)
DOI: /
Copyright © 2001 Mayo Foundation for Medical Education and Research Terms and Conditions

2. Figure 1
Genomic organization of hepatitis C virus (HCV). 5–1–1, c100, c33, c22, and NS5 are the capture antigens used for serologic diagnosis of HCV infection with the first-, second-, and third-generation assays. C = core; E = envelope; NS = nonstructural; UTR = untranslated region.
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3. Figure 2
Algorithm for the diagnosis and monitoring of hepatitis C virus (HCV) infection. ALT = alanine aminotransferase; EIA = enzyme immunoassay; IFN = interferon; SIA = strip immunoassay.
*Testing by EIA-2 should be considered in addition to qualitative HCV RNA testing.
†If clinical suspicion is high, repetition of diagnostic assays is recommended in 3 to 6 months.
‡Hepatitis C virus genotyping, quantitative HCV RNA testing, and liver biopsy may be performed together as indicated by the dashed line to expedite the patient evaluation.
§Data from Pawlotsky et al.59
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