1. Molecular Epidemiology Research and Training Program
Major Focus:
Environmental Exposures such as Smoking
Molecular Genetic Alteration such as DNA Damage
Gene-Environmental Interaction on Risk of Cancer

2. Introduction
Established in 1975, Training 5 pre-doc and 2 post-doc fellows
NCI Funded Training Program in Molecular Genetic Epidemiology of Cancer
Directed by Dr. Zuo-Feng Zhang, and co-directed by Dr. Roger Detels.
Offered by the Department of Epidemiology, UCLA School of Public Health
Currently accepting applications for pre- (PhD) and post-doctoral positions.

3. Structure of T32 Training Program

4. Research Training Opportunities
Methods in Genetic and Molecular Epidemiology
Laboratory Training in Molecular Assays
Molecular Studies of Smoking-related cancers (lung, oral, esophagus, liver, stomach, bladder)
Molecular Studies of HIV-AIDS-related cancers (NHL, KS)

5. Cancer Molecular Epidemiology Studies
Environmental Exposure and Cancer
Genetic Molecular Markers and Susceptibility of Cancer
Gene-Environmental Interaction on the risk of Cancer

6. Current Post-Doc Trainees
Dr. Amy Lee
Dr. Heather Tarleton

7. Current Pre-Doctoral Trainees
Lani Park
Sam Oh

8. Current Pre-Doc Trainees
WANG, YI REN
PECKHAM, ERIN CHRISTINE

9. Current Pre-Doc Trainees
WALLAR, GINA MARIA
NAEIM, BEHNAZ

10. G1 S G2 M
P53
Cyclin D1
P16
Environmental Carcinogens / Procarcinogens Exposures
PAHs, Xenobiotics, Arene, Alkine, etc
Active carcinogens
Detoxified carcinogens
DNA Damage
Normal cell
Carcinogenesis
Programmed cell death
Tobacco consumption
Occupational Exposures
Environmental Exposure
CYP1A1
GSTP1
mEH
NQO1
XRCC1
GSTM1
2-1. Background: Theoretical model of gene-gene/environmental interaction pathway
Ile105Val 
Ala114Val
Tyr113His
His139Arg
Pro187Ser
MspI
Ile462Val 
Arg194Trp, Arg399Gln, Arg280His
Null 
Ala146Thr
Arg72Pro
G870A
DNA damage repaired
Defected DNA repair gene
If DNA damage not repaired G0
If loose cell cycle control

11. Thank you very Much!
If you have questions regarding to the possible training opportunity and application process please your inquiry to
UCLA is Equal Opportunity Employers, and minorities are encouraged to apply.