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2003-2004 Antifungals 20 November 2018 12:58 AM.

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Presentation on theme: "2003-2004 Antifungals 20 November 2018 12:58 AM."— Presentation transcript:

1 Antifungals 20 November :58 AM

2 Amphotericin B Antifungal Polyene antibiotic
Binds to ergosterol and alters permeability Systemic

3 Inhibits synthesis of ergosterol Lanosterol 14a demethylase inhibitor
Clotrimazole Imidazole antifungal Inhibits synthesis of ergosterol Lanosterol 14a demethylase inhibitor

4 Fluconazole Triazole antifungal
Inhibits synthesis of ergosterol by inhibiting lanosterol 14a demethylase

5 Converted by fungi to 5-fluorouracil  faulty RNA and DNA synthesis
Flucytosine Antifungal Converted by fungi to 5-fluorouracil  faulty RNA and DNA synthesis

6 Griseofulvin Antifungal Binds to microtubules

7 Itraconazole Triazole antifungal
Inhibits synthesis of ergosterol by inhibiting lanosterol 14a demethylase

8 Ketoconazole Imidazole antifungal
Inhibits synthesis of ergosterol by inhibiting lanosterol 14a demethylase

9 Miconazole Imidazole antifungal
Inhibits synthesis of ergosterol by inhibiting lanosterol 14a demethylase

10 Nystatin Antifungal Polyene antibiotic
Binds to ergosterol & alters permeability Topical

11 Terbinafine Allylamine antifungal
Inhibits ergosterol synthesis by inhibiting squalene epoxidase

12 Voriconazole Triazole antifungal
Inhibits synthesis of ergosterol by inhibiting lanosterol 14a demethylase


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