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Antifungals 20 November :58 AM
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Amphotericin B Antifungal Polyene antibiotic
Binds to ergosterol and alters permeability Systemic
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Inhibits synthesis of ergosterol Lanosterol 14a demethylase inhibitor
Clotrimazole Imidazole antifungal Inhibits synthesis of ergosterol Lanosterol 14a demethylase inhibitor
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Fluconazole Triazole antifungal
Inhibits synthesis of ergosterol by inhibiting lanosterol 14a demethylase
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Converted by fungi to 5-fluorouracil faulty RNA and DNA synthesis
Flucytosine Antifungal Converted by fungi to 5-fluorouracil faulty RNA and DNA synthesis
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Griseofulvin Antifungal Binds to microtubules
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Itraconazole Triazole antifungal
Inhibits synthesis of ergosterol by inhibiting lanosterol 14a demethylase
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Ketoconazole Imidazole antifungal
Inhibits synthesis of ergosterol by inhibiting lanosterol 14a demethylase
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Miconazole Imidazole antifungal
Inhibits synthesis of ergosterol by inhibiting lanosterol 14a demethylase
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Nystatin Antifungal Polyene antibiotic
Binds to ergosterol & alters permeability Topical
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Terbinafine Allylamine antifungal
Inhibits ergosterol synthesis by inhibiting squalene epoxidase
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Voriconazole Triazole antifungal
Inhibits synthesis of ergosterol by inhibiting lanosterol 14a demethylase
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