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Volume 43, Issue 6, Pages (December 2015)

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1 Volume 43, Issue 6, Pages 1033-1034 (December 2015)
The Good, the Bad, or the Pretty: IL-17 Builds Lymphoid Tissues in the Brain  Burkhard Becher  Immunity  Volume 43, Issue 6, Pages (December 2015) DOI: /j.immuni Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 T-Helper-Cell-Induced Lymphoid Tissue Formation in the Brain
Accumulation of IL-17 and IL-22 in the meninges stimulates remodeling of meningeal stromal cells (fibroblasts and smooth muscle cells) so they develop into FRCs. LTβR engagement aids the development of FDC precursor cells, which supports B cell accumulation in the TLT. Activated FRCs in turn capture T cells and maintain their polarization and activation. Immunity  , DOI: ( /j.immuni ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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