1. Figure 5 Schematic illustration of different clinical trial designs
Figure 5 | Schematic illustration of different clinical trial designs. a | Conventional clinical trials usually randomly allocate patients into an experimental (Exp) arm and a standard treatment arm for reference. b | Trial design with stratification of patients into different treatment arms based on individual biomarkers and comparison to standard treatments. c | Umbrella trial design to compare different types of targeted treatment for a particular cancer type based on molecular profiling of the tumour in each patient followed by allocation of individualized treatment; patients with tumours that lack actionable mutations are assigned to the standard-of-care arm.
Reifenberger, G. et al. (2016) Advances in the molecular genetics of gliomas — implications for classification and therapy
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