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New Directions in iTTP
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Program Overview
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Improving the iTTP Prognosis
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Pathophysiology of iTTP
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TTP May Be Associated With Other Conditions
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Pathophysiology of iTTP (cont)
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Treatment Strategies for TTP Based on Pathophysiologic Model
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Diagnosing iTTP
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Predicting ADAMTS13 Deficiency Based on Clinical and Standard Biological Features
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Predicting ADAMTS13 Deficiency Based on Clinical and Standard Biological Features (cont)
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Unmet Needs with Current Treatment
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Managing Suboptimal Response to Therapy
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New Therapies for iTTP: HERCULES Study
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HERCULES Study: Key Results
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HERCULES Study: Secondary Endpoints
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HERCULES Study: Safety
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Recombinant ADAMTS13 for cTTP
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Recombinant ADAMTS13 for cTTP (cont)
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Preventing Relapse After Therapy for iTTP
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Preventing Relapse After Therapy for iTTP (cont)
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Outlook With New Therapies
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Changing the Treatment Paradigm
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Changing the Treatment Paradigm (cont)
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Monitoring Long-Term Complications
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Abbreviations
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