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The Central Dogma of Molecular Biology

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Presentation on theme: "The Central Dogma of Molecular Biology"— Presentation transcript:

1 The Central Dogma of Molecular Biology
REPLICATION

2 Development of multicellular organisms
All body cells are descended from a single fertilized egg cell by DNA replication and mitosis

3 Totipotency Totipotency has now been demonstrated in adult mammals with the cloning of Dolly the sheep

4 Patterns of gene expression
35,000 human genes, but only 20,000 are expressed in any one cell type Patterns of gene expression are most frequently regulated at the level of transcription

5 Gene structure coding sequence promoter terminator

6 What is required for transcription?
ATP, GTP, CTP, UTP RNA polymerase DNA template

7 The mechanics of transcription
Template-dependent Antiparallel Complementary

8 Regulation of transcription: the lac operon
Lactose  Glucose + Galactose

9 Inhibitors of transcription
a-amanitin (Amanita virosa) How long will it take to die?

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