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The Cerebral Signature for Pain Perception and Its Modulation

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Presentation on theme: "The Cerebral Signature for Pain Perception and Its Modulation"— Presentation transcript:

1 The Cerebral Signature for Pain Perception and Its Modulation
Irene Tracey, Patrick W. Mantyh  Neuron  Volume 55, Issue 3, Pages (August 2007) DOI: /j.neuron Copyright © 2007 Elsevier Inc. Terms and Conditions

2 Figure 1 Schematic Illustrating the Main Factors that Influence Nociceptive Inputs to Affect Pain Perception Neuron  , DOI: ( /j.neuron ) Copyright © 2007 Elsevier Inc. Terms and Conditions

3 Figure 2 Neuroanatomy of Pain Processing
Main brain regions that activate during a painful experience, highlighted as bilaterally active but with increased activation on the contralateral hemisphere (orange). Neuron  , DOI: ( /j.neuron ) Copyright © 2007 Elsevier Inc. Terms and Conditions

4 Figure 3 The Descending Pain Modulatory System
NCF (nucleus cuneiformis); PAG (periaqueductal gray); DLPT (dorsolateral pontine tegmentum); ACC (anterior cingulated cortex); +/− indicates both pro- and anti- nociceptive influences, respectively. Neuron  , DOI: ( /j.neuron ) Copyright © 2007 Elsevier Inc. Terms and Conditions

5 Figure 4 Current Hypothesis Regarding the Central Role of the Descending Pain Modulatory System during Different Pain Experiences RVM (rostroventromedial medulla); PAG (periaqueductal gray); +/− indicates both pro- and anti- nociceptive influences, respectively. Neuron  , DOI: ( /j.neuron ) Copyright © 2007 Elsevier Inc. Terms and Conditions

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