1. DNA
Replication

2. Why does DNA replicate?
Cells copy genetic information before cell division so that each new cell has a complete set of DNA
DNA replication occurs in the nucleus…WHY??

3. DNA Template

4. How does DNA replicate
1) UNWIND: Topoisomerase unwinds the coiled strands of DNA

5. 2) UNZIP: DNA Helicase “unzips” the strands of DNA breaking the hydrogen bonds

6. 3) HOLD OPEN: Single-Strand Binding proteins (SSBs) keep strands separated

7. 4) BASE PAIRING: DNA polymerase III bonds free floating nucleotides with nucleotides from the parent strand

8. 6) PROOFREAD:
DNA Polymerase I proofreads new strand and backtracks to correct errors

9. 5) JOINING NUCLEOTIDES: DNA ligase bonds those nucleotides together.

10. The result is 2 identical DNA molecules.

11. Each w/1 new strand & 1 old strand
Called Semi-conservative replication

13. (Continuous Replication)
(Place where replication begins)
(Replication starts & stops)

16. DNA Replication Animation

17. Talk to a Partner