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Volume 61, Issue 5, Pages (May 2012)

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Presentation on theme: "Volume 61, Issue 5, Pages (May 2012)"— Presentation transcript:

1 Volume 61, Issue 5, Pages 1054-1061 (May 2012)
Minimal Effective Dose of Dysport and Botox in a Rat Model of Neurogenic Detrusor Overactivity  Delphine Behr-Roussel, Stéphanie Oger, Bernadette Pignol, Emmanuel Pham, Amélie Le Maux, Pierre-Etienne Chabrier, Stéphanie Caisey, Sandrine Compagnie, Philippe Picaut, Jacques Bernabé, Laurent Alexandre, François Giuliano, Pierre Denys  European Urology  Volume 61, Issue 5, Pages (May 2012) DOI: /j.eururo Copyright © 2012 European Association of Urology Terms and Conditions

2 Fig. 1 Effect of intradetrusor injections of (A) Dysport and (B) Botox in spinal cord–injured rats on body weight 4 d after treatment. Data are mean plus standard error of the mean; #p<0.05, ##p<0.01, and ###p<0.001 for Dunnett’s post hoc analysis compared to vehicle. European Urology  , DOI: ( /j.eururo ) Copyright © 2012 European Association of Urology Terms and Conditions

3 Fig. 2 Effect of intradetrusor injections of Dysport on (A) amplitude, (B) frequency (contractions per min), (C) volume threshold to elicit nonvoiding contractions (NVC), and (D) intravesical baseline pressure in spinal cord–injured rats 2 d postinjection. Data are mean plus standard error of the mean; *p<0.05, **p<0.01, ***p<0.001 for analysis of variance step-down trend test compared to vehicle. European Urology  , DOI: ( /j.eururo ) Copyright © 2012 European Association of Urology Terms and Conditions

4 Fig. 3 Effect of intradetrusor injections of Botox on (A) amplitude, (B) frequency (contractions per min), (C) volume threshold to elicit nonvoiding contractions (NVC), and (D) intravesical baseline pressure in spinal cord-injured rats 2 d postinjection. Data are mean plus standard error of the mean; *p<0.05, **p<0.01, ***p<0.001 for analysis of variance step-down trend test compared to vehicle. European Urology  , DOI: ( /j.eururo ) Copyright © 2012 European Association of Urology Terms and Conditions

5 Fig. 4 Representative continuous cystometrograms of spinal cord–injured rats 2 d after an intradetrusor injection of vehicle, Dysport 10 U, or Botox 7.5 U. Arrows correspond to a voiding contraction. European Urology  , DOI: ( /j.eururo ) Copyright © 2012 European Association of Urology Terms and Conditions


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