1. What does this protein make up or do?
Chapter 1: Chromosome 1
DNA Sequence
Chromosome
1228 bp
Name of Protein 1
Name of Gene
myocilin
GLC1A
transcription
Amino acid sequence
mRNA
490 aa
translation
Cytoplasm
A Cell
Nucleus
What does this protein make up or do?
may cause increased pressure in the eye by obstructing the aqueous outflow
Condition/Disease
Glaucoma

2. Description of Glaucoma
Symptoms and characteristics
Glaucoma is an eye disease in which the fluid pressure inside the eyes slowly rises, leading to loss of vision and/or blindness.
At first, there are no symptoms
If glaucoma remains untreated, people may miss objects to the side and out of the corner of their eye, progressing to tunnel vision and blindness.
Glaucoma is detected through a comprehensive eye exam.
Normal Vision
As viewed by a person with glaucoma
Pictures used with permission from URL:

3. Description of Glaucoma (cont.)
Who is affected? Anyone, but the following have a higher risk:
African Americans over the age of 40
Everyone over the age of 60, especially Mexican Americans
People with a family history of glaucoma
Outlook or quality of life
With early treatment, eyes may be protected from serious vision loss
Without treatment, individuals develop tunnel vision (only straight-ahead vision) and, over time, no vision (blindness).
Treatments include medicine, laser procedure and/or surgery.
There is no cure for glaucoma; Vision that is lost cannot be restored.
Researcher: Jane Sample

4. References
NCBI. Genes and Disease: Glaucoma [online] [cited 2004 July 14]. Available at URL:
NCBI. Entrez [online] [cited 2004 July 14]. Available at URL:
National Eye Institute. Glaucoma: What you should know [online] [cited July 14]. Available at URL: