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Achieving and Maintaining Weight Loss in Obesity: Clinical Evidence for Novel Approaches.

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Presentation on theme: "Achieving and Maintaining Weight Loss in Obesity: Clinical Evidence for Novel Approaches."— Presentation transcript:

1 Achieving and Maintaining Weight Loss in Obesity: Clinical Evidence for Novel Approaches

2

3 Mean BMI Around the Globe in Men 18 and Over: 2014

4 The Risk for Comorbid Disease With Increasing BMI

5 Weight Loss, Metabolic, and Other Health Benefits

6 Mechanisms Involved in the Development of T2DM

7 The Link Between the Gut, Brain, Adipose Tissue, and Body Weight

8 Interventions for Weight Loss in the Overweight and Obese

9 Barriers and Complications to Obesity Management

10 EMA Approved Treatments for Weight Management Prior to 2015

11 Orlistat Reversibly Inhibits Lipases in the GI Tract

12 XENDOS: Effect of Long-term Treatment With Orlistat on Body Weight

13 Mean Changes in Coronary Heart Disease Risk Factors With Orlistat

14 Reported Adverse Effects With Orlistat Use

15 Naltrexone SR /Bupropion SR MOA to Initiate and Sustain Weight Loss

16 Effect of Naltrexone SR/Bupropion SR on Body Weight Across Multiple Trials

17 Naltrexone SR/Bupropion SR: Most Common Treatment-Emergent AEs

18 GLP-1 Secretion in the Gut and Appetite Regulation

19 Liraglutide Approval for Weight Management

20 SCALE Obesity and Prediabetes: Effect of Liraglutide on Weight at 56 Weeks

21 Liraglutide: TEAEs Reported in Phase 3 Trials

22 Liraglutide vs Orlistat For Weight Loss in Patients Without Diabetes Who Are Obese

23 Guidelines Recommendations for the Management of Obese Patients

24 Practical Weight-loss Objectives in Patients With Obesity

25 Abbreviations

26 Abbreviations (cont)

27 Abbreviations (cont)


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