1. Progression of CKD with ADMA levels above and below the median
End point
ADMA above median
ADMA below median p
Time to doubling of serum creatinine and/or renal replacement therapy (mo)
52.8
71.6
<0.0001
Fliser D et al. J Am Soc Neph 2005; Available at:

2. Clinical and laboratory measures significantly different between progressors and nonprogressors to a renal end point during follow-up
Factor
Nonprogressors (n=112)
Progressors (n=65) p
Age (y)
44.8
49.1
<0.05
Serum creatinine (mg/dL)
1.54
3.21
<0.01
GFR (mL/min per 1.73m2) 79 38
Proteinuria (g/L)
0.87
1.25
Hemoglobin (g/dL)
14.2
12.6
Intact parathyroid hormone (pmol/L)
6.5
22.5
ADMA (mol/L)
0.42
0.55
SDMA (mol/L)
0.68
1.46
SDMA=symmetric dimethylarginine
Ravani P, t al. J Am Soc Neph 2005; Available at: