1. MEDS 371, Systems Neuroscience
Pain System
Dr. D. O. Kim

2. dorsal horn of
the spinal cord

4. CGRP:
calcitonin gene
related peptide;
5-HT: serotonin

5. VR-1: vanilloid receptor type 1
capsaicin
VR-1: vanilloid receptor type 1

6. C D synapse of a C-fiber (“C”) on the dendrite (“D”)
Kandel Fig. 24-4
synapse of a C-fiber (“C”) on the dendrite (“D”)
of a dorsal-horn neuron.
small vesicles: glutamate;
large vesicles: neuropeptides.

7. discriminative pain pathways (except face/head)
anterolateral
system
(ALS);
spinothalamic
tract

8. section at lumbar spinal cord
Purves
Brown-Sequard’s syndrome
spinal-cord hemisection
section at lumbar spinal cord

9. discriminative pain pathways: face/head
trigem
gang
discriminative
pain pathways:
face/head
trigemino-
thalamic
tract

10. trigeminal pathways Haines Fig 8-9 somatosensory cortex
principal trigem.
sensory
nucleus
trigemino-
thalamic
tract
pons
trigeminal
ganglion
spinal trigem.
tract &
nucleus
medulla
Haines
Fig 8-9

11. affect: n. the conscious subjective aspect of an emotion
apart from bodily changes.
[Webster’s New Collegiate Dictionary]

12. Two distinct aspects of the experience of pain
thalamic nuclei:
midline; anterior;
mediodorsal
modified from Purves Fig 10-5

13. thamaic nuclei
Netter
CM: centromedian; LD: laterodorsal; LP: lateroposterior;
MD: mediodorsal; VA: ventral anterior; VL: ventral lateral;
VPL: ventral posterolateral; VPM: ventral posteromedial

14. thalamus
hypothalamus
cingulate
cortex
Purves Fig. A-12

15. Purves Fig. A-10
insula

16. affective
pain pathways;
unpleasant quality
of pain

17. enkephalin; dynorphin; endorphin; midbrain periaqueductal gray
endogenous opioids:
enkephalin; dynorphin; endorphin; in
midbrain periaqueductal gray
rost. vent. medulla
spinal cord

18. descending control of pain pathways
hypothalamus
Kandel
Fig 24-11

20. descending control of pain pathways
Purves Fig 10-8B

21. placebo effect a physiological response following the
administration of an inert "remedy"

22. referred pain
Kandel Fig. 24-5
Purves

23. Methods for Rainville et al., 1997
To immerse a hand in painfully hot water
(47 °C) for 75 sec;
Hypnosis: high or low unpleasantness

24. Activation of anterior cingulate cortex (ACC) by pain PET imaging of
human brains
Rainville et al 1997