1. An endothelial metronome breast cancer?
by Karen L. MacKenzie, and Richard B. Lock
Blood
Volume 108(2):
July 15, 2006
©2006 by American Society of Hematology

2. Revised model for the mechanism of metronomic chemotherapy.
Revised model for the mechanism of metronomic chemotherapy. Metronomic chemotherapy may directly affect tumor cells (brown and gray ovals), may cause direct endothelial cell death or growth inhibition (red ovals), or may decrease the mobilization or viability of bone marrow–derived CEPs, which contribute to the tumor vasculature (pink ovals). The study by Mancuso and colleagues in this issue suggests that the primary mechanism of action is via induction of endothelial cell apoptosis (green ovals). Adapted from Shaked et al3with the authors' permission.
Karen L. MacKenzie, and Richard B. Lock Blood 2006;108:
©2006 by American Society of Hematology